May 28, 2022

New review investigates the effects of omega-3 supplementation on skeletal muscle in older adults

Aging is associated with chronic low-grade inflammation, sarcopenia and functional decline. The loss of muscle mass between the ages of 40 and 80 is approximately between 30% and 60% and is associated with disability, illness, and death. Age-related musculoskeletal decline is a significant risk for falls in the elderly.

Exercise and nutritional supplementation are currently recommended as preventative against the loss of muscle and muscle strength, however, most of the nutritional studies have focused on protein supplementation. Since sarcopenia is associated with increased inflammation and impaired glucose homeostasis, omega-3-fatty have also been investigated.

According to a new review published today in Nutrients, researchers investigated the effects of omega-3 fatty acids on alone and combined with resistance exercise on skeletal muscle in the elderly.

This systemic review and meta-analysis included 15 randomized controlled trials and one randomized, non-controlled trial consisting of 2,438 participants (1,660 females, 778 males). Dosing ranged from as little as 230 mg of EPA/DHA up to 5 grams of fish oil and one study used 14 grams of flaxseed oil. The study durations ranged from 6 weeks to 36 months.

As a result, this review demonstrated that omega-3 supplementation does not impact lean tissue mass but does improve lower body strength as wells as lower body functional performance. Supplementation was effective when taken alone, but less when taken in conjunction with resistance training. No impacts were observed for walking speed.

There finding are significant as lower body strength is preferentially affected by aging and sarcopenic individuals suffer from reduced functional performance. Tests such as the timed-up-and-go and sit-to-stand test were improved with omega-3 supplementation and are important predictors of functional ability in older adults.

Omega-3 fatty acids are incorporated into the cell membranes and improve the ability to recruit motor units enhancing the neuronal activation of muscle.

These findings demonstrate a role of the effects of omega-3 fatty acids on muscle mass. Other nutrients to consider patients with sarcopenia include vitamin D, magnesium, vitamin C, collagen, BCAAs, tocotrienols, and probiotics.

By Michael Jurgelewicz, DC, DACBN, DCBCN, CNS

Source: Cornish S, Cordingley D, et al. Effects of Omega-3 Supplementation Alone and Combined with Resistance Exercise on Skeletal Muscle in Older Adults: A Systematic Review and Meta-Analysis. Nutrients 2022, 14(11), 2222.

 

New review demonstrates the benefits of blueberry supplementation in patients with metabolic syndrome

Metabolic syndrome and insulin resistance are a significant health care problem in the United States. Type 2 diabetes affects more than 300 million people.

Insulin resistance is preventable and reversible through lifestyle changes, proper nutrition, supplements, exercise and stress management. Weight loss and exercise are the best treatments for restoring the body’s ability to respond to insulin.

According to a new review published two weeks ago in Food and Function, researchers investigated the effect of blueberry supplementation on different biomarkers in patients with metabolic syndrome. Blueberries are rich in flavonoids, which contain powerful antioxidant and anti-inflammatory properties.

This review consisted of 25 studies between published between 2007 and 2021. These studies ranged from 3 weeks to 24 weeks in length with a dosage of 13 grams to 300 grams as well as two using extracts. The results of review demonstrated a significant improvement in blood pressure, triglycerides, total cholesterol, LDL cholesterol, HDL cholesterol, and insulin levels. Anthocyanins found in blueberries have a role in regulating key enzymes involved in cholesterol metabolism. All but three studies concluded that blueberry consumption positively impacted insulin resistance.

In addition, anthocyanins found in blueberries have a role in regulating key enzymes involved in cholesterol metabolism. Blueberry supplementation also showed a significant effect on body weight reduction but not waist circumference or body mass index (BMI).

A diet rich in blueberries decreases the production of free radicals due to their antioxidant capacity. This review demonstrates that blueberry supplementation should be considered in patients with metabolic syndrome.

Inositol is another nutrient that should also be considered for patients with diabetes.

Inositol acts as second messenger which regulates several hormones such as thyroid stimulating hormone and insulin.

Studies have shown that an inositol deficiency is common in patients with insulin resistance. There appears to be a reduced ability to process, metabolize, and effectively use inositol from foods which is a distinctive characteristic feature of insulin resistance. As a result, the nutritional requirements of these patients may not be met by a simple change in the diet and that inositol should be viewed as a conditionally essential nutrient in these individuals.

By Michael Jurgelewicz, DC, DACBN, DCBCN, CNS Source: Azari H, Morovati A, et al. Beneficial effects of blueberry supplementation on the components of metabolic syndrome: a systematic review and meta-analysis. Food Funct. 2022 Apr 21. doi: 10.1039/d1fo03715c

New review investigates the role of resveratrol in MCI and AD

Alzheimer’s disease and related disorders (ADRD) are a group of conditions that cause mild cognitive impairment (MCI) or dementia. These conditions affect one’s ability to function socially, personally, and professionally. It’s important to recognize that Alzheimer’s disease begins long before symptoms start just like many other conditions. There is evidence that simple prevention strategies can reduce the risk of ADRD by as much as 50%.

The prevalence of dementia for those over 65 years of age is 14% in men and 32% in women. By the age of 80, sixty three percent of those with dementia are women.

Resveratrol is a polyphenol with powerful antioxidant and anti-inflammatory properties.  It has been widely publicized for its cardiovascular, anti-carcinogenic, and anti-aging benefits.  However, researchers believe it also has positive effects on the hippocampus, an area of the brain that is critical to functions such as memory, learning and mood.

According to a recent review published last month in the Journal of Medicinal Food, researchers investigated the role of resveratrol in mild cognitive impairment (MCI) and Alzheimer’s disease (AD).

This review consisted of five RCTs studies including three studies in patients with AD and two studies conducted in patients with MCI. These studies included 201 patients: 151 patients with AD and 52 patients with MCI. The patients’ ages ranged between 49 and 80 years of age and dosing on resveratrol was as low as 5 mg up to 1 gram twice daily.  

This review demonstrated that resveratrol supplementation can be an adjuvant to a patients’ therapeutic approach. Resveratrol has both anti-inflammatory and antioxidant effects and is effective in reducing biomarkers and disease scores and as a result, improves overall cognitive performance and improves brain metabolism. This is suggestive of a protective effect of resveratrol against early metabolic decline.

Other brain supportive nutrients to consider are GPC, CDP-choline, gingko biloba, and phosphatidylserine, and fish oil. GPC and CDP-choline are water soluble forms of choline that can cross the blood brain barrier and support brain health. These help make more acetylcholine, neurotransmitters, as well as phosphatidylcholine in the cell membranes. In addition, phosphatidylserine is an essential nutrient for brain function and is not found in the diet. Research has demonstrated that phosphatidylserine improves depressive symptoms, memory, and behavior.

By Michael Jurgelewicz, DC, DACBN, DCBCN, CNS

Source: Buglio DS, Marton LT, et al. The Role of Resveratrol in Mild Cognitive Impairment and Alzheimer’s Disease: A Systematic Review. J Med Food. 2022 Mar 28. doi: 10.1089/jmf.2021.0084.

 

 

 

New study investigates the effect of zinc supplementation on blood glucose levels in type II diabetes

Insulin resistance is preventable and reversible through lifestyle changes, proper nutrition, supplements, exercise and stress management. Weight loss and exercise are the best treatments for restoring the body’s ability to respond to insulin.

Metabolic syndrome and insulin resistance are a significant health care problem in the United States. Type 2 diabetes affects more than 300 million people. Up to 15% of patients cannot take metformin because of kidney damage risks.

There are many different cofactors that can improve dysglycemia such as zinc, alpha lipoic acid, chromium, and vanadium.

According to a study published last month, researchers investigated the effect of zinc supplementation on blood glucose levels in different age groups of type II diabetes.

This randomized placebo-control trial included 144 diabetic patients. All the participants were randomly divided into Group 1 (zinc 20 mg/day) and Group 2 (control group with placebo). Each group was further divided into two age categories: category 1 (30-50 years of age) and category 2 (51-70 Years of age). Data collection included demographic data, anthropometric measurements, and a 24-h dietary recall. Laboratory assessment consisted of fasting glucose levels, HbA1C, and serum zinc levels taken at baseline and at the end of the study 60 days later. 

As a result, final fasting glucose levels were significantly lowered in the zinc supplementation group compared to placebo, however, the results were significant in the older age group (51-70 years). A similar trend was also found in the HbA1c, serum zinc levels and the BMI of the participants. These results demonstrate a better response to zinc supplementation among aged patients as compared to younger group, suggesting possible higher zinc demands with advanced age.

Inositol is another nutrient that should also be considered for patients with diabetes.

Inositol acts as second messenger which regulates several hormones such as thyroid stimulating hormone and insulin.

Studies have shown that an inositol deficiency is common in patients with insulin resistance. There appears to be a reduced ability to process, metabolize, and effectively use inositol from foods which is a distinctive characteristic feature of insulin resistance. As a result, the nutritional requirements of these patients may not be met by a simple change in the diet and that inositol should be viewed as a conditionally essential nutrient in these individuals.

Since diabetes is an increased risk factor for cognitive decline, other nutrients such as phosphatidylserine, GPC, and acetyl-l-carnitine are important. Phosphatidylserine is an essential brain nutrient that has been shown to improve the brain’s energy consumption of glucose.

By Michael Jurgelewicz, DC, DACBN, DCBCN, CNS

Source: Aslam M, Bashir S, et al. Effect of zinc supplementation on blood glucose level in different age groups of diabetes type 2. Nutr Health. 2022 Mar 29; 2601060221088382.

New study demonstrates success of IgG food antibody elimination diet patients with IBS

Irritable bowel syndrome (IBS) can be debilitating causing cramping, abdominal pain, bloating, gas, diarrhea and constipation. IBS can affect and one’s work, sleep and relationships.

Most treatments for IBS consist of medications that are often ineffective and can have numerous side effects. A low-FODMAP (Fermentable Oligo-Di-Monosaccharides and Polyols) diet is not a new treatment.

According to a study published in the Journal of Clinical Medicine, researchers compared the effectiveness of three different dietary approaches in patients with mixed irritable bowel syndrome. These dietary interventions included a low FODMAP diet, an IgG based elimination diet, or nutrition advice from a gastroenterologist.

This study included 73 female patients diagnosed with mixed irritable bowel syndrome (IBS-M). As a result, there were significant differences in the reduction of IBS symptoms found between the different approaches over an 8-week period. IBS symptoms as well as comorbid symptoms significantly improved or disappeared completely in the IgG food antibody elimination diet. These symptoms included generalized abdominal pain, abdominal pain after a meal, and abdominal pain during defecation. The low FODMAP diet did show some improvement of the IBS symptoms such as reduced mucus in the stool decreased bloating. There were no significant improvements seen by the nutritional advise by the gastroenterologist.

This study demonstrates that various dietary interventions in the treatment of IBS-M patients do not equally affect the course and outcomes of disease management and that everyone patient is unique; therefore, each dietary approach should be personalized as well.

As a result, rotation diets based on IgG food antibody elimination show significantly better results compared to other diets tested. In addition, only the IgG antibody elimination diet demonstrated significant improvements in all the monitored IBS-M symptoms as well as extra-intestinal symptoms.

It is important to note that none of the diets were shown 100% effective. By following an IgG antibody elimination diet some FODMAPs are automatically removed depending on which foods must be avoided. One possible strategy could be to start with the elimination-rotation diet and combining it with a low-FODMAP diet.

Diet is the most effective means to returning balance within the gastrointestinal system. Some patients may need a combination of botanicals, enzymes, and probiotics to optimize the gastrointestinal environment. Certain diagnostic tests may also be beneficial, including stool testing as well as food antibody testing.

The gastrointestinal tract is considered to be the body’s ‘second brain,’ it is made up of a self-contained, complex network of neurons, neurotransmitters, and proteins embedded in the lining of the GI system. It is responsible for all aspects of the digestive process, from the esophagus to the stomach and small and large intestines and may be responsible for IBS symptoms.

There are other nutrients that can support patient with IBS. For example. Perilla frutescens is an herb native to Eastern Asia that demonstrates antispasmodic, prokinetic, and anti-inflammatory effects, which help normalize and promote health bowel function and provide relief from GI symptoms. In addition, there are some specific researched strains such as Saccharomyces cerevisiae CNCM I-3856 that have been shown to reduce digestive discomfort and abdominal pain in individuals with IBS.

By Michael Jurgelewicz, DC, DACBN, DCBCN, CNS Source: Ostrowka L, Wasiluk D, et al. Igg Food Antibody Guided Elimination-Rotation Diet Was More Effective than FODMAP Diet and Control Diet in the Treatment of Women with Mixed IBS-Results from an Open Label Study. J Clin Med. 2021 Sep 23;10(19):4317.

New review demonstrates the effects of probiotic supplementation on the immune system in the elderly

As the body ages, the immune system changes and goes through a remodeling process. There is a reduction in immune cell functions which can lead to an increasing risk of infection, viral reactivation, and increased risk of autoimmune disease and cancer.

According to a review published last week in the European Journal of Clinical Nutrition, researchers investigated the effects of probiotic supplementation on natural killer cell function in healthy elderly individuals.

This review included six randomized control trials consisting of 364 healthy individuals over 65 years of age. Five of the studies used Lactobacillus alone or in combination with Bifidobacterum and one study used only Bacillus coagulans. The dosing ranged between 1 billion and 4 billion colony-forming units over a duration of 3 to 12 weeks. As a result, probiotic supplementation significantly increased natural killer (NK) activity in healthy elderly individuals. Natural killer cells are an essential part of the innate immune system and regulating the immune response. NK cells are involved in eliminating viruses and play a role in cancers and autoimmune disorders. This is the first review to only address randomized control trials and markers of NK cell function.

Accumulating research also demonstrates the association of the gut microbiome to health status and aging. There is evidence that age-related changes in the gut microbiome may be related to elevated inflammatory makers and numerous geriatric conditions such as sarcopenia, frailty, and cognitive decline. Probiotics have the potential to rebalance gut microbiota and modulate gut immune response inhibiting the NF-κB pathway as well as control microbial populations, alter cytokine expression, increase secretory IgA, increase natural killer cell activity, and reduce the risk of infections.

Previous research has demonstrated how the gastrointestinal tract changes with aging and how this impacts overall health. As one ages, the gut has an increase in interleukin 6 (IL-6) which causes the immune system to release IL-6 and trigger inflammation.

Increased levels of IL-6 directly lead to increased intestinal permeability with no physical differences seen in its structure. Researchers also demonstrated that there was an association with a decreased immune response to microbes with aging, which may contribute to an increased susceptibility to infection.

These results demonstrate that probiotics can significantly increase immune function and reduce inflammation in middle-age and older adults. Other nutrients to consider for aging, inflammation, and the immune system include tocotrienols, geranylgeraniol, resveratrol, quercetin, and specialized pro-resolving mediators.

By Michael Jurgelewicz, DC, DACBN, DCBCN, CNS Source: Gui Q, Wang A, et al. Effects of probiotic supplementation on natural killer cell function in healthy elderly individuals: a meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2020 Jun 8: 1-8.

New review investigates exercise, diet, and supplementation on the immune system and aging

As the body ages, the immune system changes and goes through a remodeling process. There is a reduction in immune cell functions which can lead to an increasing risk of infection, viral reactivation, and increased risk of autoimmune disease and cancer. These changes are affected by exercise, muscle mass, and nutritional status.

In addition, chronic low grade inflammation has been shown to contribute to almost all chronic disease and has been correlated with aging. After 40 years of age the body’s cells are typically less able to produce antioxidants and soak up free radicals making them more susceptible to damage and death.

According to a review published last month in Nutrients, researchers investigated the effects of exercise, diet, and supplementation on the immune system and aging.

Numerous studies have demonstrated the benefits of exercise on aging and the immune system. Exercise has been shown to increase natural killer cell function. In addition, cross-sectional studies in older adults in highly trained individuals, runners, and cyclists have showed improved function of the adaptive immune system including improved T-cell proliferation, reduced inflammation, and decreased thymus output.

Dietary intake of polyunsaturated fatty acids are also essential for overall health as well as impacting immune function. Studies on omega-3 fatty acid supplementation had dosing ranges of 2 to 3.3 grams per day over a duration of 3 to 6-month period. Supplementation with omega-3 fatty acids significantly reduce kynuerinine levels. Kynuernate is a metabolite of tryptophan, which is elevated in chronic low grade inflammation.

Accumulating research also demonstrates the association of the gut microbiome to health status and aging. There is evidence that age-related changes in the gut microbiome may be related to elevated inflammatory makers and other geriatric conditions such as sarcopenia, frailty, cognitive decline secondary to reduced short chain fatty acid production. Also, the immune system has a tendency to decline with age which makes one more susceptible to infections as well as increasing the risk of chronic disease. Probiotics have the potential to rebalance gut microbiota and modulate gut immune response inhibiting the NF-κB pathway. Probiotics control microbial populations, alter cytokine expression, increase secretory IgA, increase natural killer cell activity, and reduce the risk of infections.

Previous research has demonstrated how the gastrointestinal tract changes with aging and how this impacts overall health. As one ages, the gut has an increase in interleukin 6 (IL-6) which causes the immune system to release IL-6 and trigger inflammation.

Increased levels of IL-6 directly lead to increased intestinal permeability with no physical differences seen in its structure. They also showed there was an association with a decreased immune response to microbes with aging, which may contribute to an increased susceptibility to infection.

Probiotics help encourage microbial diversity, especially if the probiotic supplement is of mixed species. In ecological terms, it is more stable to have diverse populations in any ecosystem. The same is true for the gastrointestinal microbiome.

These results suggest that nutritional supplements including both omega-3 fatty acids and probiotics can significantly reduce established biomarkers of systemic inflammation in middle-age and older adults. Other nutrients to consider for aging and inflammation and the immune system include tocotrienols, geranylgeraniol, resveratrol, quercetin, and specialized pro-resolving mediators.

By Michael Jurgelewicz, DC, DACBN, DCBCN, CNS

Source: Weyh C, Kruger K, et al. Physical Activity and Diet Shape the Immune System during Aging. Nutrients 2020, 12(3), 622.

A new study demonstrates the role of vitamin D, omega-3 fatty acids, and inflammation in autism spectrum disorder

Autism spectrum disorder (ASD) has an unclear cause but is associated with various genetic, neurologic, metabolic, and immunologic factors. Although there is no definitive treatment, there has been increasing use of dietary interventions and nutritional support in these patients.

Pharmaceutical and behavioral therapies are often used but their success is limited. This can be due to the high variability of autism as well as adverse reactions to medications.

According to a new study published last Friday in the Nutrients, researchers investigated the role of vitamin D, omega-3 fatty acids, and inflammation in improving the core symptoms of ASD. A few studies have looked into this with inconclusive results. The research team hypothesized that an inflammatory state may play a role on the effect of these nutrients as well as symptoms.

This randomized, double-blinded, placebo-controlled study included 73 children ranging from two and a half to eight years of age over a 12-month period. Each child was randomly assigned to one of 4 groups: supplementation of 2000 IU of vitamin D, 722 mg of DHA, a combination of both, or placebo. Laboratory assessment included interleukin-1β (IL-1β), vitamin D 25-OH, RBC fatty acids, calcium, albumin, iron, and vitamin B12. The Social Responsiveness Scale (SRS) questionnaire was also used to assess each child’s symptoms at baseline and at the end of the study.

Elevated levels as well as genetic polymorphisms and mutations of IL-1β have been frequently reported in patients with ASD and increased levels can have negative neurological effects related to ASD as it can disrupt and cross the blood-brain barrier. Previous research demonstrated a positive correlation between IL-1β and impaired behavioral outcomes and regressive onset in children with ASD.

As a result, the research team found that both vitamin D and omega-3 fatty acids were significantly superior compared to the placebo in improving social and communicative functioning when baseline IL-1β concentrations were elevated. This study demonstrates the role and potential therapeutics in managing some symptoms of ASD in a specific subgroup of children with inflammation. This is also supports the importance of personalized treatment.

Previous research has recommended addressing deficiencies of vitamin B12, vitamin D, and essential fatty acids for their effectiveness on ASD. Folinic acid has also been shown to be to improve the symptoms of ASD.

Children with ASD may obtain most of their required nutrients from their diet, however, it is essential to determine the specific nutrient need of each child. The level of nutrient intake that maintains the best possible health is highly variable from person to person. Lifestyle choices and environmental exposures filtered through genetic predisposition are fundamental factors in ASD, and a successful treatment approach must include investigation into these factors. It is important to assess the nutrient status of the child. It is also essential to assess gut health.

Children with ASD have significantly different concentrations of certain bacteria in their stool compared to children without ASD. It is suspected that gut microbes can alter the levels of neurotransmitter-related metabolites affecting the gut-to-brain communication and alter brain function.

By Michael Jurgelewicz, DC, DACBN, DCBCN, CNS

Source: Mazahery H, Conlon C, et al. Inflammation (IL-1β) Modifies the Effect of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids on Core Symptoms of Autism SpectrumDisorder—An Exploratory Pilot Study. Nutrients. 2020 February 28; 12(3),661.

New review investigates the effects of quercetin in polycystic ovary syndrome  

Polycystic ovary syndrome(PCOS) is associated with irregular menstrual periods, infertility, obesity, diabetes, excess hair growth, acne, and other hormonal difficulties.

Pharmaceutical interventions provide some improvements but they do not correct many of the underlying factors and have side effects that may not be tolerated by patients. Many PCOS patients are overweight and have dietary habits that exacerbate the condition.

In a new review published in Journal of Ovarian Research, researchers investigated the efficacy of quercetin supplementation in patients with PCOS. Quercetin is a polyphenol that has been shown to have both strong antioxidant as well as anti-inflammatory properties and used to treat metabolic and inflammatory disorders.

This review included a combination of three human clinical trials and five animal studies evaluating the effects of quercetin in PCOS. Five of the eight studies demonstrated beneficial effects of quercetin on the ovarian histomorphology, the maturation of the ovarian follicle, and luteinization processes. These studies showed that quercetin supplementation increases normal follicles in ovaries, restores the normal ovary anatomy, and improves histology in the uterus, which is comparable to or better than metformin. Quercetin was also shown to reduce testosterone levels, luteinizing hormone (LH), and improve insulin resistance and dyslipidemia in seven of the eight studies. This was demonstrated at a dose of 25 mg/kg. Hirsutism was only evaluated in two studies, however, both studies showed quercetin improved the condition.

This review demonstrates that quercetin can correct hormonal dysfunction and improve some of the metabolic features of PCOS by its antioxidant and anti-inflammatory properties.

Other nutrients to consider to support PCOS:

Studies have shown that an inositol deficiency is common in women with PCOS. There appears to be a reduced ability to process, metabolize, and effectively use inositol from foods which is a distinctive characteristic feature of PCOS; therefore, inositol should be viewed as a conditionally essential nutrient in these individuals.

Both myo-inositol and D-chiro-inositol are essential for individuals with PCOS. Since this conversion is impaired in individuals with PCOS, it is essential to include D-chiro-inositol with myo-inositol supplementation. D-chiro-inositol is better for supporting insulin resistance and myo-inositol is needed for oocyte quality and maturation.

Also, essential fatty acids should be consumed in our diets for overall health, but most individuals with insulin resistance are deficient. Fish oils improve insulin sensitivity and reduce inflammation. 

By Michael Jurgelewicz, DC, DACBN, DCBCN, CNS

Source: Pourteymour Fard Tabrizi F, Hajizadeh-Sharafabad F, et al. Quercetin and polycystic ovary syndrome, current evidence and future direction: a systemic review.

 

 

 

New review demonstrates the efficacy of probiotics in multiple sclerosis

Multiple sclerosis (MS) is a debilitating inflammatory, demyelinating, and autoimmune disease of the central nervous system. MS is characterized by dyskinesia, cognitive impairment, numbness, fatigue, depression, anxiety, vision loss, dizziness, and gastrointestinal dysfunction.

According to a review published in Food & Function, researchers evaluated the efficacy of probiotics in multiple sclerosis.

This systemic review consisted of 22 preclinical animal studies as well as a meta-analysis of three randomized clinical trials including 173 patients with MS. As are result, the patients receiving probiotics demonstrated significant beneficial effects on mental health parameters including the expanded disability status scale scores, Beck depression inventory scores, general health questionnaire scores, and depression anxiety and stress scores.

In addition, the patients receiving the probiotic supplements showed a significant improved insulin resistance (insulin, HOMA-IR, and QUICKI), inflammatory (IL-6, hs-CRP, and NO) and oxidative stress markers (plasma TAC, GSH, and MDA).  

This study is the first meta-analysis to demonstrate a significant difference in mental health parameters (EDSS, BDI, GSH and DASS scores) among those receiving probiotic supplementation.

Preclinical studies have demonstrated that probiotic supplementation decreases the risk and severity of MS, delays MS progression, and improves motor impairment with beneficial alterations of immune and inflammatory markers as well as intestinal microbiome compositions in MS. These results show that probiotics may have beneficial effects on the prevention and treatment of multiple sclerosis.

The gastrointestinal tract is 80% of our immune system. Whenever you have inflammation present, the tight junctions and intestinal mucosa can become damaged compromising the lining of the GI tract. Then toxic byproducts in the digestive tract can be absorbed into the bloodstream forming immune complexes which eventually affect numerous systems throughout the body causing inflammation, food sensitivities and autoimmune disorders.

Gut bacteria has been identified as an important environmental factor in overall health and all autoimmune disease. Patients may need anti-microbials, botanicals, enzymes, prebiotics, and probiotics to optimize the gastrointestinal environment. 

All practitioners treating patients with autoimmune disorders should consider a comprehensive digestive stool analysis for these individuals, which modern research supports. There are several other factors that play a role in autoimmunity such as, gluten intolerance, food sensitivities, gastrointestinal infections, hormone imbalances, heavy metal toxicity, and nutrient deficiencies (ie. vitamin D, magnesium, EFAs). These environmental influences filtered through genetic predisposition are fundamental factors in the expression of disease, and a successful treatment approach must include investigation into these factors.

By Michael Jurgelewicz, DC, DACBN, DCBCN

Source: Jinchi Jiang, Chuanqi Chu, et al. Efficacy of probiotics in multiple sclerosis: a systematic review of preclinical trials and meta-analysis of randomized controlled trials. Food Funct. 2021 Mar 21;12(6):2354-2377.