Over 10% of the adult population suffer from chronic kidney disease (CKD). The two leading underlying causes of end-stage kidney disease are due to type II diabetes and hypertension.
According to a new study published yesterday in Nutrients, researchers investigated the relationship between serum vitamin D 25-OH levels and brachial-ankle pulse wave velocity (baPWV) in non-dialysis patients with stage 3–5 chronic kidney disease (CKD). Vitamin D deficiency and baPWV are both independently associated with higher incidence of mortality and cardiovascular disease or cardiovascular events.
Vitamin D has an established role in mineral homeostasis and musculoskeletal function. Vitamin D is also known to exert extra-skeletal effects including modulation of endothelial function, immune function, inflammatory responses, and cell cycle regulation.
In addition, a vitamin D deficiency has been associated with albuminuria and impaired renal function in the general population as well as all-cause mortality and kidney failure requiring long-term dialysis in pre-diabetic and type II diabetes patients.
This study consisted of 180 patients with chronic kidney disease stage three to five from a renal outpatient department between January and December 2016. Assessments included serum vitamin D 25-OH levels and BaPWV. Either left or right baPWV > 18.0 m/s was considered indicative of peripheral arterial stiffness (PAS).
In this study, 73 patients (41%) were shown to have PAS. Compared to those without PAS, patients with PAS were older and had higher incidence of diabetes mellitus, higher blood pressure, higher parathyroid hormone levels, higher C-reactive protein levels, and lower levels of vitamin D levels. As a result, lower vitamin D levels and increased age were associated with PAS in patients with CKD.
Other nutrients to consider include fiber, resistant starch, fish oil, phosphatidylcholine, and n-acetyl-cysteine or glutathione.Fish oil supplementation has been shown to decrease protein in the urine as well as protect kidney function and slow the rate of kidney dysfunction. Doses up to 10 grams per day have been used.
By Michael Jurgelewicz, DC, DACBN, DCBCN, CNS
New Review Investigates the Efficacy of Different Probiotics in IBS
Irritable bowel syndrome (IBS) can be debilitating causing cramping, abdominal pain, bloating, gas, diarrhea and…
Hashimoto’s thyroiditis and Vitamin D deficiency
Hashimoto’s thyroiditis is an autoimmune disease in which the thyroid gland is attacking its own tissue by the immune…
Glutathione is a great antioxidant for autoimmune diseases. Are you taking an absorbable form?
Glutathione is the most abundant anti-oxidant found within the human body. Glutathione is synthesized within the body…
Fiber supplements shift gut bacteria observed improves weight loss
Most Americans have a less-than-perfect diet, which is high in calories, short on nutrients, and the majority are not…
New study demonstrates success of low FODMAP diet in IBS sufferers
Irritable bowel syndrome (IBS) can be debilitating causing cramping, abdominal pain, bloating, gas, diarrhea and…
Low vitamin D levels increase risk of relapse in patients with ulcerative colitis
According to a new study published this month in the journal Clinical Gastroenterology and Hepatology, researchers…
Infant antibiotic use is linked to diseases later in life
The importance of our gut bacteria is once again in the news. A new study just published in Cell Host & Microbe…
Antibiotic use before age 2 increases risk of childhood obesity
According to new research published last Friday in Gastroenterology, researchers found that administration of three or…
New review investigates the effects of synbiotics in NAFLD
Non-alcoholic fatty liver disease (NAFLD) is an increasing epidemic in the U.S. and the rest of the world. It is the…