Women preparing for pregnancy know the importance of prenatal nutrition including a good prenatal vitamin and dietary folate but may not consider fish oil supplementation as an essential supplement during pregnancy although there are numerous studies demonstrating the effects omega-3 fatty acid supplementation and neurodevelopment. Many adults including pregnant and women preparing for pregnancy do not get as much omega-3 fatty acids as they need.

According to a study published last Thursday in the FASEB Journal, researchers demonstrated that maternal supplementation with omega-3 fatty acid supplementation during pregnancy lowers inflammatory status and increases gestational age and birth weight.

This study investigated the effects of omega-3 fatty acid supplementation in pregnant women who were at risk for preterm delivery. Microvesicles isolated from arterial cord blood were obtained from 100 human newborns. Omega-3 fatty acids are shown to be related to maternal intake due to trans-placental transportation. These newborns were divided into three groups including 60 newborns born at full term, 30 newborns born preterm, and 10 newborns born preterm from women diagnosed with a threatened preterm labor risk and were given 100 mg of omega-3 fatty acid supplementation for at least 2 weeks from the diagnosis. The results demonstrated that maternal intake of omega-3 fatty acids had a positive effect on preterm babies resulting in an increase gestational age of approximately seven days and an increase in birth weight of approximately 110 grams.

These results are consistent with a recent meta-analysis on the effects of omega-3 fatty acid supplementation of 4,193 women with an increased risk of preterm delivery. This review demonstrated a reduced the risk of early preterm delivery by 58%, increasing gestational age by an average of fourteen days and birth weight by 122 grams.

There are also other benefits of omega-3 fatty acid supplementation during pregnancy. Previous research analyzing approximately 19 studies of fish oil supplementation during pregnancy demonstrated that fish oil supplement from 20 weeks pregnant through four months of breastfeeding resulted in a reduced risk of egg allergy by 30% and peanut allergy by 38%.

In addition, fish oil supplementation for 6 weeks was shown to improve biomarkers of oxidative stress and inflammation as well as improves pregnancy outcomes in patients with gestational diabetes including lower incidences of newborn hyperbilirubinemia and hospitalization.

By Michael Jurgelewicz, DC, DACBN, DCBCN, CNS

Source: Bruschi M, Santucci L, et al. Association between maternal omega-3 polyunsaturated fatty acids supplementation and preterm delivery: A proteomic study. FASEB J. 2020 Mar 12.



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